Sle another autoimmune disorder influenced by microbes and diet

LPS might do so by inducing neutrophil activation and migration —key processes that promote the development of SLE The level of sCD14 is highly correlated with disease activity parameters, suggesting the involvement of LPS in lupus development.

Inhibition of TLR4, on the other hand, reduces autoantibody production and decreases glomerular IgG deposits in the kidney for some lupus-prone murine models The same research group also described alterations in the composition and metabolic functions of gut microbiota in SLE In their study, 2.

Amyloid fibers can tightly bind to extracellular DNA that exists in many bacterial biofilms. Systemic lupus erythematosus is an autoimmune disorder characterized by severe and persistent inflammation that leads to tissue damage in multiple organs.

Lupus: Can Gut Microbes Make a Difference?

LPS might do so by inducing neutrophil activation and migration —key processes that promote the development of SLE Thus, removal of certain gut commensals with antibiotics could potentially lead to decreases of bacterial metabolites, such as homoserine lactone, N-acetylmuramic acid, and N-acetylglucosamine 63 — which could be immunosuppressive — thereby facilitating lupus progression.

The role of environmental factors in the etiology of SLE is evidenced by the dramatic difference in disease incidence between West Africans and African Americans, both derived from the same ethnic group but exposed to different environments Our research group has recently found that, in female lupus-prone mice, there are significant reduction of Lactobacillaceae and increase of Lachnospiraceae both prior to disease onset and in the late stage of disease with severe lupus symptoms Importantly, dietary treatments that improved lupus symptoms in lupus mice also restored gut colonization of Lactobacillus and decreased that of Lachnospiraceae.

This suggests an attractive prospective of utilizing certain strains of Lactobacillus in disease management for SLE. T cell exhaustion during chronic infection may explain the ability of these pathogens to down-regulate inflammation and ameliorate SLE 49 Xin M. Despite years of study, the etiology of SLE is still unclear.

Details of TLR signaling pathways and their effects on autoimmune diseases, including SLE, have been reviewed elsewhere Vitamin D deficiency is increasingly common, resulting in increased risks for multiple disorders 68 Environmental Factors and SLE It is well established that genetic factors influence lupus susceptibility.

Elucidation of the roles of gut microbes — as well as the roles of diet that can modulate the composition of gut microbes — in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies.

However, such knowledge on SLE is little, though we have already known that environmental factors can trigger the development of lupus. In addition, bacterial metabolites produced by gut microbes can modulate immune function.

Importantly, the improvement was highly associated with the ability of tRA to restore Lactobacilli Proposed health benefits provided by the consumption of Lactobacilli include prevention of constipation, hepatic disease, infections, allergies, and as recently suggested, inhibition of autoimmune diseases such as IBD and T1D — Before the infections, both patients failed to respond to a long time of immunosuppressive therapy.

In this review, we aim to compile the available evidence on the contributions of diet and gut microbes to SLE occurrence and pathogenesis. This article has been cited by other articles in PMC.

Fecal transplant of male gut microbiota to female mice ameliorated the disease and increased testosterone. Amyloid fibers can tightly bind to extracellular DNA that exists in many bacterial biofilms. The beneficial effect is hypothesized to be associated with superoxide anion production from macrophages and modulation of prostaglandin E.

Inhibition of NETs prevents endothelial damage that promotes the progression of lupus disease 72suggesting a possible benefit of supplying VD in SLE patients with suboptimal VD levels.

This is perhaps due to the changed cytokine profile and redox status in both liver and kidney of the mice.

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

Further studies are required to verify these findings in juvenile-onset SLE, and to explore the mechanisms of why a lack of response to VD was seen in adult SLE.

Some have thus proposed that lower exposure to infections leads to the rise of allergies and some autoimmune diseases, such as T1D 34 Importantly, injection of curli-DNA composites greatly increased the autoantibody level in lupus-prone mice, and even stimulated autoantibody production in wild-type mice.

Polyunsaturated fatty acids, with the main representative being omega-3 fatty acid, have been studied as complementary or alternative treatments for SLE for many years. Both genetic and environmental factors have been implicated in the disease mechanisms.

Further studies are required to verify these findings in juvenile-onset SLE, and to explore the mechanisms of why a lack of response to VD was seen in adult SLE. In addition, in a large serologic survey, Helicobacter pylori seronegativity was found to be associated with an increased risk and earlier onset of SLE in African Americans, suggesting a protective role of H.

In contrast, due to advancements on medicine and vaccination, a number of infectious agents have been gradually eliminated in developed countries, and the sanitation condition has been largely improved. This suggests that TLR4 hyperresponsiveness to gut flora which contains LPS plays an essential role in lupus development.

Another bacterial antigen and component of bacterial biofilms, amyloid fiber curlihas been reported to induce autoantibody production Incidentally, African Americans have used antibiotics much more frequently than people in West African countries 6465and this may have impacted the differences in lupus prevalence and severity between the two populations.

Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new therapies.

· Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and provide opportunities for improved biomarkers of the disease and the potential to probe new elbfrollein.com by: Elucidation of the roles of gut microbes - as well as the roles of diet that can modulate the composition of gut microbes - in SLE will shed light on how this autoimmune disorder develops, and.

Researchers at Virginia Tech have recently discussed the contribution of diet and gut microbes to SLE occurrence and pathogenesis in a publication entitled “ SLE: Another Autoimmune Disorder influenced by Microbes and Diet?” published in the journal Frontiers in Immunology.

SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?

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Qinghui Mu 1, Husen Zhang 2 and Xin M. Luo 1 * 1 Department of Biomedical Sciences Cited by: 2. November | Volume 6 | Article Mu et al. Is SLE Infiuenced by Microbes and Diet Frontiers in Immunology | elbfrollein.com lupus symptoms in lupus mice also restored gut colonization of.

· SLE: Another Autoimmune Disorder Influenced by Microbes and Diet? Qinghui Mu, 1 Husen Zhang, 2 and Xin M. Luo 1, * 1 Department of Biomedical Sciences and Pathobiology, Virginia Tech, Blacksburg, VA, USACited by:

Sle another autoimmune disorder influenced by microbes and diet
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